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Evolv GLP-1 is an oral peptide tablet containing a proprietary yeast strain designed to naturally activate GLP-1 pathways in the body

Highlighting reduced polypharmacy and improved outcomes strengthens value propositions with providers and payers

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Plateaus during semaglutide or tirzepatide treatment are common and expected

We will continue to monitor the phenomenal up-take of GLP-1 drugs (recognizing its growing pipeline shown in the chart above) and patients perspectives of the use of these medications both those people prescribed them to treat medical obesity and those consumers willing to pay for them out-of-pocket

In addition, activating GLP-1R reduced Iba-1, IL-1 and TNF- release and inhibited TNC microglial number and morphological changes (process retraction) following nitroglycerin administration