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The activation of three receptors simultaneously makes retatrutide highly effective for blood sugar control, weight loss, and appetite suppression

Common: Nausea, vomiting, diarrhea, decreased appetite, abdominal discomfort

2025, doi: 10.1056/NEJMoa2504214

Expected Results Weight Loss Expectations Patients using semaglutide injection can expect gradual weight loss

In some cases, GLP-1s may be preferred due to their additional cardiovascular benefits, however, Mirkovic notes that GLP-1s and metformin are often used together to help manage diabetes. Summary GLP-1s have gained significant popularity in recent years, with medications like Ozempic, Victoza, Trulicity, and others being widely used

Although both medications are FDA-approved, Wegovy is approved mainly for chronic weight management, while Ozempic is indicated for blood sugar control in type 2 diabetes 1 , 2