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These symptoms typically peak during treatment initiation or dose increases

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Therefore, semaglutide, through its good regulation of lipid levels, increases insulin sensitivity in patients, effectively controls blood glucose, and slows down the progression of acute and chronic complications in patients with T2DM and issues with being overweight/obese

Although we performed sensitivity analyses adjusting for diabetes, hypertension, race, and seropositivity, residual confounding from unmeasured factors may still be present. Additionally, EHR progress notes often lacked composite RA disease activity scores, such as Disease Activity Score in 28 joints and Clinical Disease Activity Index

To update and extend the previous review, a Medline and Embase search was performed up to 21 November 2025 using the validated search strings below, with findings integrated with the previously identified evidence base (Supplementary Fig

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