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If you have Type 1 diabetes or advanced Type 2 diabetes with severely depleted beta cells, GLP-1 agonists alone will not adequately control your blood sugar

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Importantly, any observed effects appear to be indirect consequences of metabolic improvement rather than direct pharmacological actions on the adrenal glands or HPA axis

Tirzepatide , a dual GIP/GLP-1 receptor agonist, demonstrated superior efficacy to semaglutide in a landmark head-to-head trial, with patients receiving ZEPBOUND losing an average of 50 pounds over 72 weeks compared with 33 pounds among WEGOVY-treated patients

In pursuit of improved weight-loss treatments, the mechanisms of action of GLP-1 and GIP are the focus, as various treatments are being designed to mimic their effects on the regulation of glucose homeostasis, satiety, and energy balance