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This dual effectmedication-driven metabolic shift plus weight-loss-related insulation lossexplains why cold sensitivity often emerges during the first weeks of treatment when weight loss accelerates

While Mounjaro itself is not yet directly linked, its role in managing diabetes can impact the risk

However, a major shift occurred in November 2025 when the Trump administration negotiated MFN pricing deals with Novo Nordisk and Eli Lilly, reducing Medicare/Medicaid prices for Ozempic, Wegovy, Zepbound, and Mounjaro to approximately $245/month , with Medicare beneficiary co-pays of $50/month ( [17] ) ( [22] )

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3.2 Second-generation long-acting analogs The evolution developed with the emergence of second-generation GLP-1 receptor agonists, suggesting a notable advancement in molecular design and clinical application

Wang Y, Wang J, Gong Q, et al