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Renal Protection Recent evidence suggests that GLP-1 RAs exhibit significant nephroprotective effects, extending beyond their cardiovascular benefits

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We must not ignore the lifestyle changes, as the medication does the heavy lifting initially, but habits keep the weight off long-term

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Its no surprise

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It does not mean every patient must increase on this exact schedule

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The original FDA nod was based on an overall response rate (ORR) of 57% and median duration of response (DoR) that had not yet been reached in 114 patients in the Phase I/II ARROW study

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Although current data support a plausible mechanistic interaction between GLP-1-mediated weight loss and androgen signaling, direct clinical evidence evaluating combined metabolic and endocrine strategies remains limited

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