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Description
Renal Protection Recent evidence suggests that GLP-1 RAs exhibit significant nephroprotective effects, extending beyond their cardiovascular benefits
We must not ignore the lifestyle changes, as the medication does the heavy lifting initially, but habits keep the weight off long-term

Its no surprise

It does not mean every patient must increase on this exact schedule

The original FDA nod was based on an overall response rate (ORR) of 57% and median duration of response (DoR) that had not yet been reached in 114 patients in the Phase I/II ARROW study

Although current data support a plausible mechanistic interaction between GLP-1-mediated weight loss and androgen signaling, direct clinical evidence evaluating combined metabolic and endocrine strategies remains limited
