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Clinical trials have demonstrated that weight reduction occurs gradually over 12 to 18 months, with most patients reaching maximum effect within this timeframe

PMID: 8053578 [DOI] [PubMed] [Google Scholar] 57.Twersky RS, Goel V, Narayan P, Weedon J (2014) The risk of hypertension after preoperative discontinuation of angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists in ambulatory and same-day admission patients

doi: 10.1016/j.expneurol.2013.11.001 [DOI] [PubMed] [Google Scholar] 182.Marxreiter F, Regensburger M, Winkler J

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Soft tissue and altered biomechanics in patients with a high BMI can make surgical exposure and component placement more challenging, leading to prolonged operative times