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This was despite some concerns outlined in briefing documents regarding Lillys trial methodology, including its use of the integrated Alzheimers Disease Rating Scale (iADRS) as the primary endpoint, the use of tau protein levels to decide study inclusion and the cessation of donanemab treatment in patients whose brain amyloid levels dropped past a certain, pre-specified threshold

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doi:10.1016/S1474-4422(09)70062-6 181

CONCLUSIONS A unifying view, provided by integrative physiology and sometimes called a holistic approach, is especially important for understanding how the brain acts, regulates all functions of the living body and at the same time is regulated by body signals [95]

Program Structure: Both offer personalized plans and support