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Your GP can provide evidence-based management options , including lifestyle advice, medication review, prescription of PDE5 inhibitors if appropriate, and referral to specialist services if needed

Eating smaller, more frequent meals instead of large meals can also reduce reflux

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Early-phase data, though limited, provide valuable insights into dose-response relationships, efficacy signals and safety profiles that inform ongoing and future trials

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Patient-specific factors also play a roleindividuals with pre-existing GERD, those taking higher doses, and patients with delayed baseline gastric emptying may experience more pronounced symptoms