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The 3,5-dimethyl-4-fluoro-phenyl ring interacts with residues in TM1 and TM7, bridging these two helices and stabilizing their relative orientation

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It can also connect food with CGM glucose data when available
Pharmaceutical Acta Helvetiae, 50(1), 99-107
Since semaglutide slows gastric emptying and alters gut motility, adding a laxativeparticularly stimulant typesmay lead to variable responses in different patients

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