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There were no statistically significant interactions by treatment and background medication subgroup for change in HbA1c or body weight except for change in HbA1c (background insulin vs insulin plus metformin) in PIONEER 8 (p=0.0408)

Both compounds belong to the growing class of incretin-based weight loss medications that target GLP-1, GIP, and glucagon receptors to help patients lose weight, improve blood sugar control, and reduce liver fat