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Data were analyzed using one-way ANOVA, followed by Tukeys test for a and b (right panel) and two-way ANOVA, followed by Tukeys test for b (left panel)
By coupling GLP1-R agonist and GIP agonist together (seen in Tirzepatide), reduced reward-seeking behavior induced by the former may be strengthened by the enhanced mTOR effect of the latter, reinforcing neural circuits involved in executive control and decision-making, potentially counteracting the dysregulated reward pathways seen in addiction (Figure 3) [46,51]

The pill is also approved to help reduce the risk of serious cardiovascular events like nonfatal heart attacks and strokes
Dapagliflozin Restores Insulin and Growth Hormone Secretion in Obese Mice

Endocrinology (2008) 149:405968
