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251 When the GLP-1 analogue liraglutide was administered to patients with psoriasis (an inflammatory disease associated with obesity and diabetes) this led to a decreased psoriasis area severity index, and cytokine secretion was decreased from natural killer cells in a glycaemic control-independent manner

Regulatory Approvals and Guidelines: As GLP-1 receptor agonists receive more regulatory approvals and are recommended in treatment guidelines for diabetes management, their adoption in clinical practice continues to grow, further solidifying their position in the market

This research highlights that there are several studies under development that may bring additional results in the continuation or replication of the use of SMG in patients with obesity and/or DM2 but also investigate new combinations (e.g., combination with dehydrated cannabidiolNCT06648031) compared to new drugs (NCT06649344, NCT06604624, NCT06579105, NCT06577090, NCT06497049, NCT06282458, and NCT05616013) and may even expand the indications for other pathological conditions (associated or not with obesity or DM2), such as steroid-induced diabetes (NCT06318442), acute myocardial infarction (NCT06557811), autosomal dominant polycystic kidney disease (NCT06582875), steatohepatitis associated with metabolic dysfunction (NCT06492330 and NCT06374875), obesity-related asthma (NCT05254314), cystic fibrosis (NCT05788965), advanced interstitial lung disease (NCT05746039), psoriasis vulgaris (NCT06475586), systemic scleroderma (NCT06149260), idiopathic intracranial hypertension (NCT06361823 and NCT06027567), post-acute stroke (NCT05630586 and NCT05920889), neuroleptic-related prediabetes in individuals with schizophrenia (NCT05193578), Alzheimers (NCT06072963 and NCT05891496), functional hypogonadism (NCT06489457), polycystic ovary syndrome (NCT05646199, NCT05702905, NCT06222437, and NCT05819853), endometrial hyperplasia (NCT05829460), Klinefelters syndrome (NCT05586802), or even in alcohol consumption disorder (NCT05520775, NCT05891587, NCT05895643, and NCT05892432), opioid use (NCT06548490), or cocaine use with and without human immunodeficiency virus (NCT06691243), among many other potential therapeutic indications