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Description
Managing gastrointestinal side-effects and preventing treatment discontinuation with GLP-1 therapies GI symptoms are the most common adverse effects of GLP-1 therapies, with nausea, constipation, diarrhea, and vomiting occurring in around 40 % of patients [11,[30], [31], [32]]

Both groups underwent lifestyle modification interventions

These data strongly suggest that alpha cells have GLP-1R under diabetic conditions

The added glucagon receptor increases resting energy expenditure, promotes liver fat clearance (82% reduction vs ~55%), and contributes to greater overall weight loss (28.7% vs 22.5%)

When these fibres are fermented by gut bacteria, they produce compounds called short-chain fatty acids (SCFAs) such as butyrate, propionate and acetate

Malone et al., 2009)
