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We also briefly review the effects of GLP-1R agonists on PD and discuss how the successful use of these substances in preclinical models of PD has paved the way for PD clinical trials

Hormones play crucial roles in glucose metabolism

Alzheimers prevention deserves better than extrapolation

However, it is worth noting these improvements may reflect the physiologic consequences of rapid weight loss rather than reversal of underlying disease mechanisms, and whether such changes would persist without definitive obesity treatment is unknown

Mouse GLP-1R CHO cells were cultured in Hams F12/DMEM (1:1) with L-glutamine (Invitrogen) supplemented with 10% FBS and 0.8 mg/mL geneticin

doi: 10.1016/j.eclinm.2024.102726 [DOI] [Google Scholar] 88.Holscher C