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According to our experience in rats, the parenteral administration of ghrelin at a dose that raised plasma hormone to the level observed under fasting conditions, significantly attenuates plasma levels of leptin, while markedly increasing food intake

These are absolute contraindications based on animal study findings

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[2] [3] At lower doses, weight reductions ranged from approximately 8% to 17% depending on the dose group

These events are dose-dependent and most pronounced during dose escalation