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Journal of Clinical Endocrinology & Metabolism , 109(4), 12341246

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For GLP1R: The full human GLP1R coding sequence was inserted into mouse Glp1r exon 1, disrupting the mouse gene and driving human protein expression via the mouse promoter

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Introduction The glucagon-like peptide-1 receptor (GLP-1R), expressed in pancreatic beta cells amongst other tissues including brain, lung, stomach, and heart, is activated by the incretin peptide hormone GLP-1, secreted from enteroendocrine L-cells after food intake (1), to regulate postprandial glucose levels via the potentiation of glucose-dependent insulin secretion (24)