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In a trial involving adults with obesity but without diabetes, those on the highest dose lost up to 21% of their body weight over 72 weeks

The FDA label aligns with practical guidance: small, lower-fat, protein-forward meals

Preventative semaglutide and tirzepatide treatment does not alter disease progression in the 5xFAD mouse model of Alzheimer's disease "Incretin therapy does not alter the progression of AD neuropathology in 5xFAD mice Neuroinflammation is not prevented by incretin therapy in LPS-treated mice." cell.com/cell-reports-m

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the analysis included data collected before permanent discontinuation of study intervention and was conducted using the efficacy analysis set