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The hypothalamus (particularly the melanocortin circuit) is a classic model that is susceptible to upregulation of developmental compensatory pathways that mask food intake and body weight phenotypes (Wu & Palmiter, 2011

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This could suggest that the drug has protective effects on the brain, potentially extending its benefits beyond glucose control in diabetic patients

Trapp S, Stanford SC

doi: 10.1016/j.iac.2004.03.011