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Intussusception, a condition where part of the intestine telescopes into itself, can cause blood in the stool, particularly in infants and young children

Spacing doses at least 3 days apart prevents this risk

With age, our metabolism naturally slows down, making it challenging to convert food into energy, leading to fat accumulation

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Practical implementation also depends on clinical interpretability, technical accessibility, and alignment with existing care pathways

Dropout was higher in the 12 mg arm than in the 9 mg arm, reinforcing a pattern already visible in Phase 2: the marginal efficacy gain from pushing to 12 mg comes at real tolerability cost