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Continued tirzepatide: Lost an additional 5.5% Total weight loss at 88 weeks: 25.3% 89.5% maintained at least 80% of their weight loss Switched to placebo: Regained weight Total weight loss at 88 weeks: 9.9% Only 16.6% maintained at least 80% of their weight loss This trial demonstrates that tirzepatide works best as ongoing treatment and that stopping medication typically leads to significant weight regain
The prescribing information does list dyspepsia (indigestion) as a common adverse reaction, which is characterized by epigastric discomfort or pain

This safety feature reduces hypoglycemia risk compared to insulin or sulfonylurea medications

Monthly semaglutide prescriptions soared from 0.7 million in June 2021, when Wegovy became FDA-approved, to 2.6 million in February 2024
Some reviewers flagged this as a significant gap, especially compared to providers like DrWell that include basic labs in their program pricing

This is where a peptide calculator combined with a high-quality syringe makes a real difference
