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The recognition that ligands can differentially bias receptor signaling toward distinct intracellular pathways has reframed how efficacy and toxicity are understood

Instead of HbA1c levels, insulin dose adjustments should be made to ensure that the Time-in-Range (TIR) level improves, as this metric is derived from continuous glucose monitoring (CGM)

Smits MM, Tonneijck L, Muskiet MH, Hoekstra T, Kramer MH, Diamant M, et al

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These findings demonstrate the potential of GLP-1s in directly addressing neurological conditions where inflammation and dysregulated signalling are central issues

Co-administration of exenatide [13], lixisenatide [36], liraglutide [19], dulaglutide [32, 38] or semaglutide [27, 40] resulted in decreased C max and delayed t max of acetaminophen (Table 3)