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The prevailing model held that these drugs act directly on GLP-1 receptors in the brain, while our study provides evidence for an alternative pathway. For this study, the researchers used the weight-loss drug liraglutide, marketed under the brand names Victoza and Saxenda
However, in rats after VSG, glucose infused slowly and directly into the duodenum caused similar increases in GLP-1 as when the same glucose load was delivered orally (26)
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doi: 10.1016/j.ejphar.2017.07.015 [DOI] [PubMed] [Google Scholar] 31
& Bray, G
But it wouldn't exist without it
