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Semaglutide the active ingredient in Wegovy and Ozempic works through a single hormonal pathway and follows a different dosing schedule with a much lower maximum dose of 2.4 mg weekly

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The observed divergence in mortality results when comparing injectable semaglutide to sitagliptin (a placebo proxy) in benchmarking analyses led us to view the results for outcomes containing mortality with skepticism and focused our interpretation on the nonmortality clinical endpoints

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