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Description
Efpeglenatide is a long-acting GLP-1RA, which was developed for the management of hyperglycemia in patients with T2D [50]

In some studies, lean mass has accounted for a meaningful portion of total weight lost
Compounded GLP-1 medications are not FDA-approved finished drug products

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The deeper story, supported by emerging research, is that NAD+ may be upstream of GLP-1 production entirely

Functional changes in the microbiota of low-gene-count patients primarily consist of a decrease in butyrate-producing bacteria and an increase in the ratio of Akkermansia to Ruminococcus gnavus , which lead to decreased methane production potential, decreased hydrogen production potential, enhanced mucus degradation, and increased peroxidase activity (le Chatelier et al., 2013)
