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Effectiveness Clinical trials have suggested that orlistat provides modest weight loss in people with obesity but also may lead to digestive side effects

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In addition, exendin-4 differs from mammalian GLP-1 by a series of amino acids in the central and C-terminal domains that include Leu10, Lys12, Gln13, Met14, Glu16, Glu17, Tyr19, Arg20, Leu21, Glu24, Lys27, Asn28, and Gly30

These medicines mimic a natural gut hormone, stimulating insulin release only when blood sugar is elevated, which reduces the risk of dangerously low glucose levels

however, the risk of congenital anomalies following such exposure is not known

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