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[8] SURPASS-2 : Tirzepatide (5, 10, 15 mg) reduced HbA1c by 2.01%2.30%, compared to 1.86% with semaglutide (1 mg)

Futhermore, 2025 results from the ATTAIN-MAINTAIN trial demonstrated orforgliprons ability to compete in the maintenance segment

In parallel, Nooms intensive behavioral platform ensures that patients actually follow through on the diet and exercise recommendations that are meant to accompany the drug, thereby amplifying weight loss and fostering habit change that can last a lifetime

Many individuals with type 1 diabetes gain weight due to intensive insulin therapy, so adding a GLP-1 agent may help counter this effect

Its broad utility in hematologic malignancies and post-transplant complications, along with steady payer demand, has cemented Jakafi as a cornerstone JAK-STAT inhibitor, delivering reliable growth despite increasing competition

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