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And at the maximum 12 mg dose, 10% reported feeling tired

Through systematic analysis of clinical trials, meta-analyses, and emerging evidence from landmark studies like SELECT, this paper evaluates whether GLP-1 agonists represent a transformative breakthrough or an overhyped intervention with significant limitations

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In contrast, tirzepatide, a dual GLP-1 RA (GIP/GLP-1 RA) [1], was associated with a markedly larger effect, with a pooled mean difference of - 23.80 events/hour (95% CI: 29.62 to 17.98