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Oral GLP-1 receptor agonists are also in the development phase, with preliminary data showing efficacy similar to that of Semaglutide

It should be commenced at a dose of 5 mg daily, which can be increased to 15 mg daily as required.Ertugliflozin is currently contraindicated in people with an estimated glomerular filtration rate less than 45 mL/min/1.73m 2

The GLP-1/DPP-4 axis is a promising target for neurological disorders such as Alzheimers disease, Parkinsons disease, and neuropathic pain [32]

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Long-term effectiveness, sustainability of weight loss, and disease-modifying capacity in nonmetabolic disease must also be prioritized in future research