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Seek immediate medical attention for blood clot symptoms including leg swelling, chest pain, sudden breathlessness, or signs of pulmonary embolism

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Add in less food = less fuel to burn = lower body heat

GLP-1 receptor agonist drugs (such as semaglutide) can also reduce water intake by affecting areas in the brain responsible for thirst

(Kunutsor and colleagues, review, Drugs , 2025

When -MSH binds to MC4R neurons in the paraventricular nucleus (PVN) of the hypothalamus, it induces a signalling cascade that ultimately results in decreased appetite