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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

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Concern about GLP therapy, bone density, and fracture risk

Compared to semaglutide alone, the combination resulted in significantly greater weight loss, better body composition, and reductions in visceral fat and inflammation

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