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Interestingly, GCG was also shown to bind the GLP-1R, although it has about 140 times less affinity for GLP-1R than the specific agonists of these receptors (Chepurny et al

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Drugs 78(11):11131132 [DOI] [PMC free article] [PubMed] [Google Scholar] dAquino AI, Maikawa CL, Nguyen LT, Lu K, Hall IA, Jons CK, et al (2023) Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management

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Physicians prescribe GLP-1 agonists such as semaglutide, liraglutide, tirzepatide, and dulaglutide for the management of type 2 diabetes mellitus and weight management for obese patients
