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Glucagon-like peptide-1 (GLP-1) is an incretin hormone derived from the transcription product of the proglucagon gene, primarily secreted by intestinal L-cells in response to nutrient intake [1]

Methods: In a randomized controlled trial, 52 healthy obese individuals were, after a diet-induced 12% body weight loss, randomized to treatment with or without administration of the GLP-1RA liraglutide (1.2 mg per day)

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Wootten et al., 2013c), but the equivalent mutation in rat GLP-1R had no major effect (Xiao et al., 2000)

Studies have shown that patients on these medications, combined with lifestyle changes, can achieve substantial weight loss, often in the range of 15% to over 20% of their total body weight, making them a powerful tool in the fight against obesity

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