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Activating both receptors can improve insulin secretion, enhance fat metabolism and amplify appetite suppression

As the field advances, humanized preclinical systems that allow drug evaluation against human targetssuch as GCGR/GIPR/GLP1R humanized mouse modelswill play a pivotal role in bridging the gap between mechanistic discovery and clinical translation

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69 GLP-1 RA has been shown to interfere with UPR to protect against NDs