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Over 65 Older adults can take weight-loss injections, but there are some additional considerations: Dehydration risk: gastrointestinal side effects can cause dehydration, which is more dangerous in older people and can worsen kidney function or cause falls Muscle mass: older adults already lose muscle with age, and rapid weight loss accelerates this

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Semaglutide binds to blood proteins and pools in subcutaneous tissue, so the effective pace at which it leaves you depends on how fast it moves out of those reservoirs, not just the single-number half-life printed on a label

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