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Tirzepatide activates receptors in your hypothalamus and other brain regions that govern satiety signals, meaning your brain genuinely feels satisfied with less food

Ideal candidates for Klinic's weight loss treatments are adults with a BMI of 30 or higher or a BMI of 27 with one or more weight-related conditions like high blood pressure or sleep apnea

doi: 10.1080/00325481

GLP-1 signaling can get lost in the noise of inflammation, because L-cells are both hormone and immune-releasing cells

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Dehydration from gastrointestinal side effects may also play a role