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The GLP-1 component slows gastric emptying, inhibits glucagon and dampens appetite via the satiety centre in the hypothalamus

While less well characterized, SIRT2 is important too

However, this recent study published in the Journal of American Medical Association raised concerns about potential ophthalmic complications associated with these drugs

Using a linear trimming estimator in the trim and fill model, one study was attributed to the left side of the funnel plot
