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As demand for weight-loss drugs rises, states grapple with Medicaid coverage Some researchers question long-term cost savings for state programs In this photo illustration, boxes of the diabetes drug Ozempic rest on a pharmacy counter

CONFLICT OF INTEREST JPHW reports receiving advisory board fees, paid to his institution, from Astellas Pharma, grant support and fees for membership on a data and safety monitoring board, both paid to the University of Liverpool, lecture fees and travel support from AstraZeneca, advisory board fees, paid to his institution, and lecture fees from Boehringer Ingelheim, Napp and Sanofi Pasteur, advisory board fees, paid to his institution, from Eli Lilly, Janssen Global Services, Rhythm and Wilmington Healthcare, lecture fees from Mundipharma, grant support, advisory board fees and fees for serving as an investigator, all paid to the University of Liverpool, and lecture fees from Novo Nordisk and advisory board fees from Takeda Medical Research Foundation

Mice were dosed ICV every 4 days for 5 treatments

doi: 10.1053/j.gastro.2007.03.054 [DOI] [PubMed] [Google Scholar] 16

The investigators recorded "cardioprotective" drops in blood pressure with pemvidutide and no clinically meaningful jumps in heart rate

Patients with active liver disease, severe renal impairment, or unstable cardiovascular conditions require extra caution