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Yes, melatonin and tirzepatide work through separate biological pathways and have no documented contraindications

No and heres why that works in your favor

doi: 10.1016/j.atherosclerosis.2013.08.033

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This paper adds to growing evidence that GLP-1 receptor agonists may have an oncologic impact by improving metabolic health, said Paunel Vukasinov, MD, a dual board certified internist and obesity medicine specialist at Medical Offices of Manhattan
