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In this way, we only included new SGLT-2i or GLP-1RA users with obesity when initiating therapy, in order to produce groups as similar as possible at baseline

Some people do well on GLP-1s and need all the help they can get, and increase doses every four weeks like clockwork until they reach the maximum

doi: 10.1053/j.gastro.2004.04.063 259 KosinskiJRHubertJCarringtonPEChicchiGGMuJMillerCet al

Probiotic and microbiome-supportive routines tend to work gradually, and Cleveland Clinic notes that benefits are generally expected over the longer term, while a human Akkermansia study in overweight and obese adults evaluated results over 3 months rather than a few days

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