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[DOI] [PubMed] [Google Scholar] 29.Smits M.M., Tonneijck L., Muskiet M.H., Kramer M.H., Pouwels P.J., Pieters-van den Bos I.C., Hoekstra T., Diamant M., van Raalte D.H., Cahen D.L

2,339 participants were randomised to retatrutide 4mg, 9mg or 12mg weekly (titrated from 2mg in four-weekly steps) or placebo

A separate consumer analysis published in December 2025 examined SynergyRx's platform verification indicators, including stated LegitScript certification, published provider credentials with verifiable NPI numbers, and operational transparency factors

However, the mechanism of action of semaglutide and its effects on the endocrine system, particularly the thyroid gland, remains an area of ongoing research
