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For Wegovy, patients are eligible if they have a body mass index, or BMI, at or over 27

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[DOI] [PubMed] [Google Scholar] 29.Smits M.M., Tonneijck L., Muskiet M.H., Kramer M.H., Pouwels P.J., Pieters-van den Bos I.C., Hoekstra T., Diamant M., van Raalte D.H., Cahen D.L

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2,339 participants were randomised to retatrutide 4mg, 9mg or 12mg weekly (titrated from 2mg in four-weekly steps) or placebo

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A separate consumer analysis published in December 2025 examined SynergyRx's platform verification indicators, including stated LegitScript certification, published provider credentials with verifiable NPI numbers, and operational transparency factors

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However, the mechanism of action of semaglutide and its effects on the endocrine system, particularly the thyroid gland, remains an area of ongoing research

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