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Table 8 indicates Mpro substitutions and combinations of Mpro substitutions that have been found to reduce nirmatrelvir activity 3-fold (based on IC50 or Ki values) in biochemical assays using recombinant SARS-CoV-2 Mpro

And it activates glucagon receptors, which increase energy burn

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GLP-1 RA treatment for alcohol use disorders)

Other variants suggest you'll respond better to tirzepatide (a dual GIP/GLP-1 agonist) than semaglutide alone

According to previous studies (Guo et al., 2023