surmount-1 tirzepatide obesity nejm 2022 weight loss percent Tirzepatide: In the trial, reduction percentages were dose-dependent: 5 mg: ~15.0% weight reduction. 10 mg: ~19.5% weight reduction. 15 mg: ~20.9% weight reduction (Jastreboff et al., 2022). https://www.nejm.org/doi/10.1056 Tirzepatide for maintenance of bodyweight

Clean the skin with an alcohol swab, pinch a fold of skin on your belly, thigh, or upper arm, insert the needle at a 90-degree angle, and push the plunger slowly

The first four to eight weeks For most people, the most intense fatigue occurs during the first 4 to 8 weeks of treatment

A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation with MOUNJARO

Gual-Grau, A., Guirro, M., Boque, N

When tirzepatide is discontinued, the pharmacological effects that supported weight loss gradually diminish