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Growth hormone stimulates hepatic IGF-1 production by binding to growth hormone receptors on liver cells, triggering intracellular signaling through the JAK2/STAT5 pathway that upregulates IGF-1 gene expression

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We found that Ab68 treatment had effects on fibrosis and body weight comparable to those of dietary supplementation with nicotinamide ribose (NR), a NAD + precursor 24

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