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This work exemplifies how scaffold engineering and ZBG optimization can converge to deliver potent, selective, and pharmacokinetically viable anticancer leads

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[6] Proposed mechanisms for cardiovascular benefits of incretin-based therapies include: Vascular effects : Improved endothelial function and reduced arterial stiffness Anti-inflammatory actions : Decreased systemic inflammation and oxidative stress Metabolic improvements : Enhanced insulin sensitivity and reduced hepatic glucose production Hemodynamic changes : Blood pressure reduction, though with modest increases in heart rate Renal protection : Reduced albuminuria and preservation of kidney function The cardiovascular benefits appear partially independent of weight loss itself, suggesting potential cardioprotective properties of incretin pathway activation

however, semaglutide delays gastric emptying and may affect absorption of oral medicines, including stimulants

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Pain assessment Joint nociception was evaluated using the von Frey test (tactile allodynia)