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3 Cardiovascular and renal disease models Preclinical models of atherosclerosis, hypertension, heart failure, and chronic kidney disease (CKD) enable scientists to determine how GLP-1R agonists influence vascular health

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Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes

In addition, the inhibition of EndMT, the attenuation of inflammation and apoptosis are also responsible for reversing endothelial dysfunction with GLP-1RA treatment (Figure 2)