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In the past ten years, a series of Phase III trials showed that the synthetic GLP-1/GIP agonists are effective in lowering blood sugar in type 2 diabetic subjects who were both treatment-nave or on typical first-line therapies such as metformin and insulin

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Preclinical models supported a direct mechanism, with exendin-4 protecting dopaminergic neurons and reversing motor deficits (Perry et al., 2002

It is projected to become the top-selling drug globally in 2026, surpassing all competitors Emarketer