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De Groot AS, Roberts BJ, Mattei A, Lelias S, Boyle C, Martin W (2023) Immunogenicity risk assessment of synthetic peptide drugs and their impurities

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13,140 Animal studies have shown that neutral antagonists appear to decrease food consumption and weight gain similar to Rimonabant, but unlike this drug they do not inhibit activity in areas of emotion regulation, such as the ventral tegmental area and the basolateral amygdala

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