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doi: 10.1155/2013/801457, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 5

TSH (thyroid-stimulating hormone): Hypothyroidism can mimic or worsen weight gain

Al-Aly said he was inspired to do the study by the story of statin drugs, like Lipitor, which are prescribed to treat high cholesterol

Findings from pancreatic -cell and other GLP-1Rexpressing models may not fully recapitulate exocrine gland physiology, and future human or experimental salivary-gland studies are needed to validate these mechanistic possibilities

Using several hormones in low doses and incorporating lifestyle interventions might maximize the clinical effect while minimizing the side effects. Clearly, many patients would find daily injections of hormones preferable to undergoing bariatric surgery, even if these injections would need to be continued in the long-term to keep the weight off

More research efforts are needed to develop guidelines regarding GLP-1 RA dose adjustments or discontinuations before such procedures and to improve both, procedural and patient-related, outcomes
