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Endoplasmic reticulum stress in pancreatic beta cells induces incretin desensitization and beta-cell dysfunction via ATF4-mediated PDE4D expression

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Similarly, the sample size in the TRIUMPH1 knee OA basket is designed to provide at least 90% power to detect a clinically meaningful benefit of retatrutide 9 and 12 mg versus placebo in the change in WOMAC pain subscale score, assuming each dose is analysed separately in parallel using a Satterthwaite t test at a 2sided significance level of 0.0125, accounting for differences that have been observed historically in variability between placebo and active arms